By way of the state program of reforming well being care and the Regulation «On safety of residents' well being» have been built-in (joint) with analysis of ecology of surroundings with the participation of ecologists, mineral-geochemists and well being staff. Industrial Facilities (Tashkent-Angren-Almalyk, Tashkent, Navoi-Bekabad-Zarafshan, and so on.) during which the inhabitants is because of the intensification of technological processes and the growing load-nano structured aerosol pollution are vulnerable to related illnesses. Wastes from manufacturing, enters the environment, soil, water and vegetation with their unmanageable accumulation (overload) the influence of per individual, inflicting a concomitant illnesses (dental, pores and skin, and so forth.), in addition to the wildlife. Trendy civilization has immunosuppressive results on the human physique with a set of associated illnesses, together with the expansion of dental protection to working-age inhabitants [4,12]. On this regard, an essential scientific issues of sensible significance is drawn hygienic monitoring of the setting business analysis facilities with structural and mineral aerosol nano element (so-called «spit some») mass of air [11,14] on the antigen-toxicants.
Within the industrial facilities the sources of harmful pollution for human well being (antigen-toxicants) are shaped geologically and geochemical (or biogeochemical) antropo genious, biologically and cosmogeneous and different brokers and processes happening within the context of surrounding setting.
Geology - and geochemical sources of superb formed, nano structured and different mass disintegration and weathering of pure magmatic, metamorphic and sedimentary rocks and ores, together with city buildings, and their subsequent transport and accumulation in aerosol formation.
Geological - geochemical elements of air pollution over an enormous territory, however truly associated aerosol (spit some) mass richly represented in mineral elements of nano structured types (Desk 1 and a couple of) whose elements by Si, Al, Fe, Ca, Cu, and so forth., are important within the improve of concentrations which purchase significance for the organism antigen-toxicant. In typical aerosol elements the presence of a set of TR (uncommon earth parts, with 15), radioactive (U, Th, and so forth.) are of greater than 70 gadgets by all the definitions.
In a focus of an aerosol mud the upkeep of aerosol aluminum (are extraordinarily excessive, from much less 10-74 to 20 weight.). In response to trendy representations [5,6,11] aluminum exhibits focus at any maintenances in nano construction to the discovering type, and so, nano elements, nano meeting and nano structured aluminum allocation require the particular strategy – sanitary-and-hygienic laws. To itself of the same strategy of researches the type of keep of silicon which being in nano mineral dynamic values causes nano buildings get the significance of dangerous to an organism pollutes (an anti genetic - toxicants) surroundings.
By geographical elements forming aerosol pollution by merchandise of marine origin fumes aerosols iodine, bromine, chlorine, and probably others. Within the environment of city and suburban options of the economic facilities of progress aerosol sulfur, fluorine, phosphorus, chlorine and different pollution are thought-about in relation to industrial actions (hydrogenous, sulfur dioxide, hydrogen sulfide, methane, and so on.). Aerosol elements of technogenic origin is extraordinarily harmful to the human physique, which weakens its pure protecting mechanisms that favor the event of quite a few illnesses, together with dental (caries and its problems non caries defeat onerous tissue of tooth, periodontal illnesses and illnesses of the mucous membrane of the mouth). Trendy strategies of prevention and remedy of dental illnesses in industrial facilities, with an unfavorable ecological state of affairs just isn't all the time conducive to their full restoration. Extended remedy of illnesses of periodontal and mucous membrane of the mouth typically result in the event of varied problems (progress of resistant types, and allergic reactions related to the illness and others).
Atrophy genious (industrial) sources of aerosol air pollution of the environment are attribute of areas of main industrial facilities (Chirchik chemical manufacturing unit, Ohangaron cement manufacturing unit, Bekabad Metallurgical Plant, Almalyk hard-rock-metal Mill and so on.), which makes a sure contribution to the aerosol hassle. Working automobiles worsen the environmental state of affairs. Atrophy genious pollution on the elements  when the formation is expanded: work on automobiles (as much as 40% of the full variety of Pollutant aerosol character) on the work of commercial enterprises, quarrying excavation of rocks and ores (40%) to get rid of waste manufacturing, and different particles, agricultural manufacturing (20%). Irregular (man) aerosol pollution provoke improvement of great illness organism (allergic, endocrine, cardiovascular, urological, pores and skin, dental and so forth.).
Cosmogenic sources of atmospheric aerosol elements are concerned within the dissemination of Fe, Mn, Ti, Si, N, C, Be, Li, B, and different chemical compounds. Cosmogenic radiation is accompanied by the formation of radioactive isotopes of carbon (12S14), hydrogen (1N3), beryllium (1Be7) and different radioactive isotope of carbon (12S14), with a half-T u003d 5568 years, happens because of the influence of neutron (n) for isotopes of nitrogen (N14): N14 + n → 12S14 + H1. Isotope of helium (He3) represents the product of the response of the dissolution of tritium (H3). Cosmogenic origin is and the radioactive isotope (1Be7), forming by splitting atoms of nitrogen and oxygen: 1Be7 [N14 + n → Be7 + ..] and 1Be10 with a half-T u003d 53 days, respectively, and T u003d 2.7 ∙ 106 years. Radioactive isotopes of carbon, beryllium, hydrogen and different chemical parts in rainwater enters the overall circulation, are sometimes adsorbed on the clay supplies, structural elements of soil natural substrate, and so on. Bio elemental practical and natural violations of the organism are due to antigen - aerosol pollution of commercial facilities. The human physique is characterised by the participation of nearly all chemical parts . Units of chemical parts within the matrix of the human physique at a mean weight (Desk Three) are divided into macro and micro parts.
The mineral composition of the human physique incorporates  the next macro-and micronutrients:
macro and micro-elements :
% contents from weight, %
By means of the digestive system, respiration organism happens replenish chemical parts, in addition to «chilly fusion» via the transformation of some chemical parts within the different. Within the physique, with extra accumulation of parts or their lack of content material develops a set of useful and natural irregularities provoked bio elemental (elemental). Setting business Facilities additionally instantly or not directly results in useful and natural violations of the human physique (bio elemental). Within the mobile matrix and the complete bodily physique, or the shortage of surplus wanted for very important chemical parts provokes periodontal illness, and so on. The shortage of a chemical factor is offset by different, associated, however alien to the organism aspect, for instance, Sr-90 is analogous to the construction of Ca (Group II A).
Comparable chemical parts (Desk 1 and three) are outlined of the group : H, Li, Na, Okay, Rb, Cs, Fr - Group IA; Be, Mg, Ca, Sr, Ba, Ra - Group II A; B, Al, Ga, In, Tl -- Group III A; C, Si, Ge, Sn, Pb - Group IV A; N, P, As, Sb, Bi - Group V A; O, S, Se, Te, Po - Group VI A; F, Cl, Br, I, At - Group VII A; Fe, Ru, Os - Group VIII A; Co, Rh, Ir - Group IX A; Ni, Pd, Pt - Get together XA; Cu, Ag, Au - Group XI IB; Zn, Cd, Hg - Group XII II B; Sc, Y, La, Ac - Group XIII III B; Ti, Zr, Hf - Group XIV IV B; V, Nb, Ta - Group XV VB; Cr, Mo, W - Group XVI VI B; Mn, Nc, Re - Group XVII VII B; He, Ne, Ar, Kr, Xe, Rn - Group XVIII O; La, Cc, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tt, Yb, Lu - Group XIX Lanthanide; Ac, Th, Pa, U, Np, Pu, Am, Cm, Bk, Cf, Es, Fr, Md, No, Lr - XX actinide group.
Sr-90 - radioactive, happens within the setting (soil, water, aerosols), industrial facilities, collaborating in the identical chemical reactions, that Ca, Ba - 140 or Ra-226. Within the physique strontium - 90 accrued, consisting of bones and tooth impacts the smooth tissues, frightening the event of most cancers. Antigen-aerosol pollution, impact on the physique to impress extreme illness (bio elemental, practical and natural violations, together with the continual type). Inadequate variety of chemical parts within the physique provoke illness related to gipomikroelementozis (micro elemental), and the surplus of discovering results in gipermikroelementozis (hyper micro elemental).
Some our bodies selective (focused) accumulate within the construction, some chemical parts (iodine - within the thyroid gland; fluoride - within the enamel tooth; zinc - within the genital organs, pores and skin, hair, pancreas, iron - within the erythrocytes). Iodine biologically needed mineral element of the thyroid gland and is a vital hint component within the formation of hormones of the gland. In case of scarcity iodine physique replenished by radioactive J-131, which is excessively amassed within the thyroid, and irradiated surrounding tissue and organs might provoke the event of prostate most cancers. Virtually all of the radioactive iodine is current within the spray of mud, which may take part within the replenishment of the physique.
Macro-and microelements in human physique are crammed with radioactive analogs, or a gaggle of comparable parts: Ca ← Sr-90; J ← J-131; Fe ← Pu-238, 239; Okay ← Cs-137; S ← S-35, vitamin B12 ← Co-60; Zn ← Zn-65. Irradiation and launched into the physique of radioactive elements provoked organ carcinogenesis, the formation of most cancers foci, the expansion of so-called «Free radicals», damaging cells, tissues and dwelling organism as an entire. Selectively accumulate within the lungs following nuclides (Kr-85; Pu-238, 239; Ra-233; Xe-133135), liver (Cs -137; Co - 58, 60; Np - 239; Pu - 238, 239, 241), thyroid gland (J - 129, 131; Tc - 99), pores and skin (S - 35), spleen (Po - 210), ovarian (Ba - 140; Cs - 134, 137; Co - 58, 60; J - 131; Kr - 85; Pu - 239; Ru - 106; It - 90; Zn - 85), bone (Ba - 140; C - 14; Eu - 154, 155; P - 32; Pu - 238, 239, 241; Pm - 147; Ra - 136; Sr -- 89,90; Th - 234; U - 233; It - 90; Zn - 65), muscle mass (Cs - 134, 137; Eu - 164, 155; Okay - 40, 42).
Within the aerosol mud (Desk 1) industrial facilities are greater than 70 chemical parts of: organical; macro parts; vitally-needed micronutrients; conditional life-necessary hint parts, probably poisonous hint parts (Rb, Zr, Sn, Au, Ag, W, Ge, Ga, Sr, Ti) and poisonous hint parts (Al, Pb, Ba, Cd, Hg, Tl, Be, Sb). Within the physique by way of the respiratory system comes nano structured elements of the Ba (20%), Bi (20), Cd (20), Tl (20), Be (40), Sb (20), Zr (40), Sn (20), Ag (20), W ( 20), Ga (20), Ti (20) and others within the nano structured type of residence. Within the aerosol nanostructures elements most poisonous and probably poisonous hint parts, whereas in lots of excessive concentrations (100 - 1000 occasions) are indicators of the risks bio elemental manifestations and related illnesses.
Within the aerosol progress of antigenic toxins favor, above all, the unfold of dental and different illnesses. Recognized that the incidence of dental caries and illnesses largely resulting from climatic and geographical terrain. Dental examinations have been made with inhabitants protection of the economic facilities. It was discovered that the geographic location in a extra vital extent than fluoride impacts the depth of dental illnesses. When contemplating the depth of dental caries in adults aged 35-44 years residing in 13 city and rural factors of Uzbekistan discovered that the depth (KPA) varies extensively, specifically from 15,40 to 15,44-affected tooth within the cities Djizzak and Nukus - as much as 5,28 within the metropolis of Urgench [1,3,10].
In accordance with epidemiological research the prevalence of dental caries within the grownup inhabitants of the Republic of Uzbekistan establishes within the quantity of 95,Four% (limits of fluctuations of 90.66% to 97, 51%), the depth of CPU on common, near 10,60 per surveyed. In the middle of epidemiological analysis it turned evident of the influence of setting on the magnitude of prevalence and severity of dental caries. To begin with, drew consideration to the issue of residence in city or rural areas, in addition to the influence anthropo genious pollution. Within the city inhabitants affected by caries have been extra probably than rural. For instance, in Tashkent the prevalence of dental caries was 97,51 ± Zero,56%, surpassing goal set for rural residents in Kibray district of Tashkent area. In Andijan, the prevalence and depth dental caries statistically considerably greater than the corresponding figures in Shahrihan district of Andijan area (Desk Four).
Prevalence of dental caries amongst adults within the Republic of Uzbekistan (in% of the quantity surveyed)
60 и ст.
Uzbekistan has a excessive prevalence of illnesses of tissues periodontal. The primary nosological types of illnesses periodontal is periodontitis. Research present that amongst adults the prevalence of periodontitis in Tashkent is 61.20 +Zero.75 (see Desk 5).
Prevalence of periodontitis within the grownup inhabitants within the Republic of Uzbekistan (in% of quantity surveyed)
65 as much as hundred
In the identical climatic and geographical circumstances of the area a better frequency of periodontitis is established among the many rural residents than the town., the comparatively low degree of registration of the prevalence of periodontitis in Tashkent metropolis than in rural areas, an indicator for the comparatively top quality of remedy and prevention of illness. Evaluation of literature on the epidemiology illnesses, confirmed that, throughout quite a lot of elements affecting the frequency of their prevalence, determinants present oral hygiene, the character of energy and standing of ecological surroundings. It must be famous that among the many illnesses periodontitis, occurring in rural areas in the primary group falls quickly progressive periodontitis- agressiv type of periodontitis (STDs). Within the etiology of STD calls particular consideration to the ecology of the setting and this issue are likely to deal with the «illness of the XXI century» [2,8]. A survey of rural residents, primarily, work involving contact with chemical compounds permits to watch a better incidence STDs.
For the territory of Uzbekistan is characterised by a pointy continental local weather, scorching summers, the winter is extreme, typically had heavy snowfalls. Mountain areas with comparatively flat areas are characterised by the deposition of atmospheric precipitation in plentiful portions, with sharp fluctuations in temperature. The rise within the variety of dental illnesses is happening towards the backdrop of worsening environmental stress on the human physique, excessive insulation and UV radiation. Together with dental caries and its problems happens a pointy improve in illness periodontal. Dental illness and regional - and international environmental surroundings, in fact, are in a sure interdependence. Aerosol polluters, scary bio elemental [1,8,9] favors a rise within the variety of dental illnesses. The character of those communications, although, and finds statistical proof, requires examination, staging and sanitation of environmental monitoring and surveys of residents on the illness.
Chemical compound of nano structural mineral part of aerosols of commercial facilities of Uzbekistan (on 20 checks of an aerosol-dust focus, in common)
Weight , %.
Nano structural mineral elements of aerosols of commercial facilities of Uzbekistan
Sources of producing muddies (dusts)
The mineral type of a discovering
Helpful want of nano structural from quartz and its varieties, dioxide silicon (chalcedonies, opals, and so on.).
Area spars; nano structural varieties
Sa Carbonates varieties; lime, burnt lime, nano structural elements of Sa,
Soot, carbonaceous substance, natural mineral formations, and so forth.
Elemental sulfur, pyrite, sulfur nanostructures
Silitsity Fe; ferrite, Cohen, oxides and Fe hydroxide
Silitsity Mn; oxide and hydroxide Mn
Organo-mineral type nanostructured sort
Organo-mineral type nanostructured sort
Organo-mineral (cluster) varieties
Cluster (nanostructured) types
Cluster (nanostructured) varieties
Nanostructured; organo-mineral type
Nanostructured; clustered type
Cl, B, Br
NOTE: XXX - widespread; XX - comparatively widespread; X - the least.
1. In industrial zones (Tashkent-Chirchik-Ahangaran-Almalyk, and so on.), aerosol nano structured mineral biogeochemical antigen-toxicant and different environmental contaminants within the surroundings as a organic and physiological exercise of frightening the event of bio elemental, practical and natural violations of the human physique.
2. Towards the background of geological and geochemical, organic, antropogenic, cosmogenic and environmental impacts movement formation and distribution of aerosol antigen - toxicants and different air pollution areas. The character of geological and geochemical aerosol pollution is extraordinarily numerous, their specificity and nanostructured elements are shaped with the involvement of Si, Al, Ca, Fe, Mn, C, S, P, Cl, and so on. The composition of the aerosol matrix natural matter (fuel and high-quality spit some, smoke and gas-liquid), with sorption exercise favor a number of progress and focus of «typical», in addition to «Alien» (Au, Pd, Ag, and so on.) and different nano structured and mineral elements.
Three. The elements of organic origin (P, S, P, Okay, Si, Fe, and so forth.), formation of which cross by way of the cotton and horticultural land, in addition to greenhouse farming, soil cowl (nitrogen Fuel-liquid Schooling with traces of «heavy» metals and different antigen-toxins), fires, combustion of waste, rubbish and considerably contribute to the general cycle of aerosol pollution.
Four. Antropogenic (industrial) aerosol pollution accompany locations human life (work motor automobiles, industrial emissions, launching area automobiles, and so forth.), revealing to the units of elements of the aerosols from Si, Al, Ca, As, Sb, Hg, Cu, Zn, and so forth., together with a couple of uncommon earth chemical parts. For the physique, this issue of aerosol air pollution setting represents a really excessive danger, as collateral might manifest within the type of extreme allergic reactions of the organism, have bronchial asthma, irritation and irritation of the mucous membrane of eyes, mucous membranes of the oral cavity and different organs.
5. For Cosmogenic sources of formation of nano structured elements of aerosols are characterised by the involvement and participation of Be, Fe, Mn, Si, N, C, B, Li and others Cosmogenic radiation provokes the formation of various different extremely harmful for the physique of radioactive isotopes of carbon (12S14), hydrogen (1N3), beryllium (4Ve7) and different chemical parts, that are carbon-protected elements of aerosols are actively adsorbed to nano structured type. Means of their accumulation in aerosols concomitant is hostile in environmental aerosol territory.
6. Matrix aerosol consists of greater than 70 nano structural chemical parts, together with uncommon, uncommon earth and radioactive. Within the aerosols are current organogenic (C, H, N and O), macro parts (Ca, P, S, Okay, Na, Cl, Mg), is necessary-(Fe, Zn, Cu, Mn, Mo, Co, Cr, Se, I) and conditional life-necessary (F, B, Si, Ni, V, Br, Li, and so on.), hint parts, in addition to antigen-toxicant (Al, Pb, Ba, Bi, Hg, Tl, Be, Sb), and probably - the poisonous parts (Rb, Zr, Sn, Au, Ag, W, Ge, Ga, Sr, Ti). Antigen-toxicant, and potential - the poisonous elements of aerosols, have an effect on the physique to impress bio elemental, useful and violations of the natural physique. 7. To a big extent, the incidence of dental caries and periodontal resulting from illness climatic and geographic options of terrain. City inhabitants affected by caries extra typically than the agricultural inhabitants, by way of antropogenic (industrial and industrial emissions, the car) aerosol pollution. In Tashkent the prevalence of caries tooth was 97,51 ± Zero,28% and better than measured for rural district of Tashkent area Kibray 96,55 ± Zero,98%. In Andijan, the incidence and severity of dental caries statistically considerably greater than that of Shahrihan space of Andijan area (94,93 ± Zero,94 and 90,66 ± 1,42, respectively).
Eight. In the identical climatic and geographic area, a better frequency of periodontitis established amongst rural residents than city areas. However for rural residents, primarily the work, which is held in touch with chemical compounds there's a greater incidence of STDs, which in a short time results in lack of tooth.
9. Variety of dental illnesses in inhabitants of commercial zones seen in virtually a weak tolerance and indifference to the influence of aerosol nano structural antigen-toxicants.
This work was supported by the Committee for the Coordination of the event of science and know-how within the CM of Uzbekistan (grant A-7-388).
The literature record
1. Alimsky A.V.Bogatssky V. A, and so forth. «The Evaluation of requirement of the inhabitants within the dental assistance on supplies of routine inspections». Perfection of organizational types of the dental assist to the inhabitants: works Central scientific and analysis institute of stomotology. М, 1986, P.9-13
2. Bezrukova I.V., Gryadunov A.I. "Aggressive types of the periodontitis . M.: The Moscow publishing company.2002. P.11.
Three. Bekzhanova O. E «The Standing of tooth and materials periodontalis at grownup inhabitants of Republic Uzbekistan and a means of perfection of dental assist». Writer presentation. Candidate of medical sciences. Tashkent. 1993. P.17.
Four. Gaffarov S.A., Olimov S.S., Saidov A.A., and so on. «The Dental standing of primary working industries of Uzbekistan» Tashkent: 2006. P.206
5. Gusakova N.V. "Environmental Chemistry". Rostov on Don: the Phoenix. 2001. P.183.
6. Courtroom F, Bakhir I, Klein V. "Ecologic chemistry" М: World. 1997. P. 396.
7. Pavlov V. I «Concord and well being. System of diagnostics and therapeutic of the individual». Sensible steerage. Penza: «Gold part». 2006. P.232.
Eight. Rizaev J.A. «Clinic - practical indicators of a present periodontitis and options of remedy». Writer presentation. Candidate of medical sciences.. Tashkent: Tashkent Medical Academy. 2006. P.21
9. Rocky A.A. "Chemical aspect in physiology and ecology of the individual." М: The World. 2004. P.215.
10. Shadiev Okay.Okay. «The Epidemiological state of affairs, depth of caries of tooth and illnesses periodontalis and effectivity of their preventive upkeep at youngsters». Writer presentation. Candidate of medical sciences. 1983.-P.21
11. Jusupov R. G, Shukurov AD, Kodirov O. SH. "Anti gene muddies at industrial territories of Tashkent-Angren-Almalykskoj surroundings". The gathering «Precise issues of geology and geophysics». Tashkent: "Fan". II. 2007.P. 279-282.
12. Jusupov S.H. "Standing periodontalis at some a part of the inhabitants of Republic Uzbekistan". //New in dentistry. Tashkent. 1998. №Four. P.13-18.
13. Cooke J., Dzau V.J. "Nitric oxide syntheses: position within the genesis of vascular illness" //
Annual. rev. Biochem. 1994. V.48. P. 489-509.
14. Kodirov O., Yusupov R., Shukurov N. "The antigenic pollution in air soils (Close to-Tashkent industrial space, Uzbekistan)". 33-IGC. Oslo.2008 file://33-IGC 1254995.html.
15. Моnkada S., Higgs A. "The L - arginini - No pathway" //N. Engl. J.Med. 1993. V.329.